上皮間充質轉化(EMT)與創傷修復研究進展
首發時間:2011-12-13
摘要:上皮間充質轉化(epithelial-mesenchymal transition, EMT)是指上皮細胞在某些生理或病理條件下失去上皮細胞特征并獲得間充質細胞特征的生物學過程,其間涉及復雜的調控網絡與分子機制。根據其在不同的生物學過程中起作用分為三個類型。在創傷修復的復雜過程中,表皮細胞經歷EMT過程進行再生重建表皮層,對該過程進行深入研究對于創傷修復乃至干細胞與組織工程具有潛在意義。本文就此予以綜述。
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Epithelial-mesenchymal Transition and Wound Healing
Abstract:Epithelial-mesenchymal transition (EMT) is a biological process that epithelial cells lose polarity to be mesenchymal-like cells and acquire the ability of migration and invasion, involved in complex regulation network and molecular mechanisms. EMTs are classified into three different biological subtypes based on the biological context. Keratinocyte-driven re-epithelialization in wound healing recapitulates several aspects of EMT. Lucubrating about it has potential significance on wound healing and stem cell and tissue engineering.
Keywords: cell biology epithelial-mesenchymal transition wound healing epidermal cell
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