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            Increase in Concentration of Soluble CD86 After Segmental Allergen Challenge in Patients With Allergic Asthma *

            施煥中 , Xiang-Dong Liang , MD; Huan-Zhong Shi , MD , PhD; Xue-Jun Qin , MD; and Jing-Min Deng , PhD




            Study objective: To investigate the effects of segmental allergen challenge on the concentration of soluble CD86 (sCD86) in BAL fluids in patients with allergic asthma. Methods: BAL fluid and peripheral blood were collected at baseline, 24h after segmental saline solution or allergen challenge by fiberoptic bronchoscopy and venepuncture, respectively, from 10 patients with allergic asthma. Total and differential cell counts in BAL fluid were performed, and sCD86 levels in both BAL fluid and serum were measured by enzyme-linked immunosorbent assay. Results: In allergic asthmatics, there was no significant increase in BAL sCD86 concentrations after saline solution challenge (median, 2.0IU/L; 25th to 75th percentiles, 0 to 3.4) compared with baseline control subjects (median, 1.2IU/L; 25th to 75th percentiles, 0 to 3.6IU/mL; p 0.735); however, sCD86 concentrations were significantly elevated after allergen challenge (median, 8.1IU/L; 25th to 75th percentiles, 4.4 to 17.0IU/mL; p<0.001). The concentrations of sCD86 in BAL fluid after allergen challenge exceeded levels that could be accounted for passive transudation from the circulation, based on the magnitude of increases in BAL albumin concentrations. Conclusions: These data indicate that allergen challenge results in a significant local accumulation of sCD86 within the airways, and that the local release of sCD86 may play a role in allergen-induced inflammatory processes in the asthmatic airways.

            關鍵詞: airway , allergy , asthma , bronchoscopy

            【免責聲明】以下全部內容由[施煥中]上傳于[2006年10月27日 20時13分23秒],版權歸原創者所有。本文僅代表作者本人觀點,與本網站無關。本網站對文中陳述、觀點判斷保持中立,不對所包含內容的準確性、可靠性或完整性提供任何明示或暗示的保證。請讀者僅作參考,并請自行承擔全部責任。


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