<track id="j575v"><span id="j575v"><th id="j575v"></th></span></track>
<address id="j575v"></address>

    <video id="j575v"><progress id="j575v"><progress id="j575v"></progress></progress></video>

      <p id="j575v"></p>

      <form id="j575v"><dl id="j575v"></dl></form>
      <video id="j575v"></video><nobr id="j575v"></nobr><video id="j575v"></video>
        <track id="j575v"></track>

        <pre id="j575v"></pre><big id="j575v"><span id="j575v"></span></big>

            您當前所在位置: 首頁 > 學者


            • 25瀏覽

            • 0點贊

            • 0收藏

            • 0分享

            • 139下載

            • 0評論

            • 引用


            CCL22 Recruits CD4-positive CD25-positive Regulatory T Cellsinto Malignant Pleural Effusion

            施煥中 , Xue-Jun Qin , Huan-Zhong Shi , Jing-Min Deng , Qiu-Li Liang , Jing Jiang , and Zhi-Jian Ye

            Clin Cancewr Res 2009; 15(7) April 1, 2009 2231-2237,-0001,():



            Purpose: The aim of this study was to explore the presence of the chemokines CCL22 and CCL17 in malignant pleural effusion, and the chemoattractant activity of these chemokines on CD4-positive CD25-positive Foxp3-positive reg ulatory Tcells infiltrating into the pleural space. Experimental Design: The concentrations of CCL22 and CCL17 in both pleural effusions and sera from 33 patients with lung cancer were determined. Flow cytometry was done to determine T lymphocyte subsets in cell pellets of pleural effusion. Pleural cells were analyzed for the expres-sion of CCL22 and CCL17. The chemoattractant activity of CCL22 for regulatory Tcells in vitro and in vivo was also observed. Results: The concentration of CCL22 in malignant pleural effusion was significantly higher than that in the corresponding serum. Pleural fluid from lung cancer patients was chemotactic for reg-ulatoryTcells, and this activity was partly blocked by an anti-CCL22, but not by an anti-CCL17 antibody. Intrapleural administration of CCL22 0f patients produced a marked progressive influx of reg ulatory T cells into pleural space. Conclusions: Compared with serum, CCL22 seemed to be increased in malignant pleural effu-sion, and could directly induce reg ulatory T cell infiltration into the pleural space in patients with malignant effusion.


            【免責聲明】以下全部內容由[施煥中]上傳于[2009年10月27日 19時54分00秒],版權歸原創者所有。本文僅代表作者本人觀點,與本網站無關。本網站對文中陳述、觀點判斷保持中立,不對所包含內容的準確性、可靠性或完整性提供任何明示或暗示的保證。請讀者僅作參考,并請自行承擔全部責任。


            全部評論 0